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Proses deteksi ini dimulai ketika sistem kekebalan mengenali epitop pada antigen. Epitop adalah subregion kecil pada antigen yang mensimulasikan pengenalan kekebalan. Perubahan dari pembuatan vaksin potensial dalam jumlah kecil ke pembuatan galon vaksin yang aman dalam situasi produksi dramatis, dan prosedur laboratorium sederhana mungkin tidak